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Deep Brain Stimulation (DBS)

At the 6-week, posttreatment assessment, the researchers observed a greater reduction in YBOCS score among patients who received active dTMS treatment than among those who received sham treatment reductions of 6 points vs. The response rates were higher in the active group compared with the sham group after 6 weeks The most frequent adverse event was headache Disclosure: Carmi reports research and travel support from Brainsway.

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What is Deep Brain Stimulation?

Rapid theta-burst stimulation mimics natural brain waves to stimulate neurons and relieve treatment-resistant depression. But how beneficial is a shorter treatment session?

Deep brain stimulation provides sustained relief for severe depression -- ScienceDaily

If one simple innovation can make a product 10 times faster without sacrificing performance, that would be considered a monumental breakthrough in many technological circles. Such an innovation occurred in psychiatry last year when the Food and Drug Administration FDA cleared a new form of transcranial magnetic stimulation TMS for treatment-resistant depression that requires only three minutes per session—as opposed to up to 40 minutes needed for conventional TMS therapy.

The arrival of this rapid neuromodulation approach, known as theta-burst stimulation TBS , could significantly increase access to a proven depression therapy because more patients can be treated at TMS clinics every day. Conventional TMS pulses magnetic waves at a frequency of 10 hertz Hz , typically for 5 to 10 seconds. These pulses are continually repeated with short breaks in between for 20 to 40 minutes depending on the machine—hence why the treatment is referred to as repetitive TMS.

enter site George, who led much of the preclinical research with TMS as a depression therapy, acknowledged that the 10 Hz level was chosen more by art than science. If TBS is magnetic stimulation optimized, then that frequency is 50 Hz, delivered in three, rapid bursts totaling a fraction of a second. This pattern mimics the natural theta waves fired off by neurons in the brain.


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TBS allows physicians to speak back in the same language, George continued. By generating magnetic waves more in sync with natural rhythms, neurons can become stimulated much more quickly—in three minutes, or even faster. Following success in some preliminary studies, the clinical efficacy of TBS was confirmed in a large, multisite, head-to-head study that compared TBS to the clinically available standard: repetitive Hz TMS. The study findings were published in Lancet in April This new method of delivery is just far more efficient.

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George noted that the study compared two active treatments, and patients knew which one they were receiving. ECBSP aims to promote collaboration between European clinicians and researchers working on advancing brain stimulation in psychiatry. First Name:.


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